We’re using 2-photon microscopy to record neuronal activity with single-cell resolution in the hippocampus of awake, behaving mice. Taking advantage of cell type-specific viral targeting of various biosensors, our goal is to better understand how distinct populations of excitatory and inhibitory neurons are recruited during network oscillations in the healthy brain, and during pathological activity such as seizures in the epileptic brain.
Quynh Anh Nguyen
I utilize in-vivo and in-vitro electrophysiology, 2-photon calcium imaging, and EEG recording to study the role of inhibitory circuits and signaling molecules in epilepsy. Ultimately I want to help develop a comprehensive understanding of how neurons in the brain communicate with each other, the molecular and circuit mechanisms underlying their proper functioning, and how dysfunction in critical components of neuronal communication leads to neurological disease.